Principales propiedades fisicas ? ¿ toxicidad? Uso del mismo?
1 Respuesta
Respuesta de fsarro
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fsarro, Médico en ejercicio, especialista en Nefrología
Soy médico, no farmacéutico. Si tu consulta es para un trabajo de farmacia, te has equivocado de experto. Si buscas información médica sobre dicho producto, centrado en un tratamiento aplicado a un paciente concreto, házmelo saber y te ampliaré la información MÉDICA que precises. Si entiendes el inglés, lo siguiente quizá te pueda ayudar (extraído de Lexi-comp y UpToDate): ____________ Sulfabenzamide, sulfacetamide, and sulfathiazole: Drug information Author Copyright 1978-2006 Lexi-Comp, Inc. All rights reserved. U.S. BRAND NAMES - V.V.S.® Pharmacologic category Antibiotic, Vaginal DOSING: ADULTS - Haemophilus vaginalis vaginitis: Intravaginal: Cream: Insert 1 applicatorful in vagina twice daily for 4-6 days. Dosage may then be decreased to 1/2 to 1/4 of an applicatorful twice daily. DOSING: ELDERLY - Refer to adult dosing. DOSAGE FORMS - Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Cream, vaginal: Sulfabenzamide 3.7%, sulfacetamide 2.86%, and sulfathiazole 3.42% (78 g with applicator) Dosage forms: concise Cream, vaginal: Sulfabenzamide 3.7%, sulfacetamide 2.86%, and sulfathiazole 3.42% (78 g with applicator) V.V.S.®: Sulfabenzamide 3.7%, sulfacetamide 2.86%, and sulfathiazole 3.42% (78 g with applicator) Generic equivalent available - yes USE - Treatment of Haemophilus vaginalis vaginitis ADVERSE REACTIONS SIGNIFICANT - Frequency not defined. Dermatologic: Pruritus, urticaria, Stevens-Johnson syndrome Local: Local irritation Miscellaneous: Allergic reactions CONTRAINDICATIONS - Hypersensitivity to sulfabenzamide, sulfacetamide, sulfathiazole, or any component of the formulation; renal dysfunction; pregnancy (if near term) WARNINGS / PRECAUTIONS Concerns related to adverse effects: Blood dyscrasias: Severe reactions including agranulocytosis, aplastic anemia and other blood dyscrasias have occurred with sulfonamides (regardless of route). Dermatologic reactions: Severe reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis have occurred with sulfonamides (regardless of route). Hepatic necrosis: Fatalities associated with fulminant hepatic necrosis have occurred with sulfonamides (regardless of route). Hypersensitivity reactions: Rarely, systemic hypersensitivity reactions may occur; use caution if applying to denuded or abraded skin. Sulfonamide allergy: Chemical similarities are present among sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, thiazides, and loop diuretics (except ethacrynic acid). Use in patients with sulfonamide allergy is specifically contraindicated in product labeling, however, a risk of cross-reaction exists in patients with allergy to any of these compounds; avoid use when previous reaction has been severe. DRUG INTERACTIONS - No data reported PREGNANCY RISK FACTOR - C (show table) (avoid if near term) LACTATION - Excretion in breast milk unknown INTERNATIONAL BRAND NAMES - Sultrin (AE, BF, BH, BJ, CI, CY, EG, ET, GH, GM, GN, GR, IL, IQ, IR, JO, KE, KW, LB, LR, LY, MA, ML, MR, MU, MW, NE, NG, OM, PH, PT, QA, SA, SC, SD, SL, SN, SY, TN, TZ, UG, YE, ZA, ZM, ZW) MECHANISM OF ACTION - Interferes with microbial folic acid synthesis and growth via inhibition of para-aminobenzoic acid metabolism PHARMACODYNAMICS / KINETICS Absorption: Absorption from vagina is variable and unreliable Metabolism: Primarily via acetylation Excretion: Urine PATIENT INFORMATION - Complete full course of therapy; notify prescriber if burning, irritation, or signs of a systemic allergic reaction occur ____________