sulfatiazol

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a
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principales propiedades fisicas ? ¿ toxicidad? uso del mismo?
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Hola.
 
Soy médico, no farmacéutico. Si tu consulta es para un trabajo de farmacia, te has equivocado de experto. Si buscas información médica sobre dicho producto, centrado en un tratamiento aplicado a un paciente concreto, házmelo saber y te ampliaré la información MÉDICA que precises.
 
Si entiendes el inglés, lo siguiente quizá te pueda ayudar (extraído de Lexi-comp y UpToDate):
 
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Sulfabenzamide, sulfacetamide, and sulfathiazole: Drug information
Author
Copyright 1978-2006 Lexi-Comp, Inc. All rights reserved.


U.S. BRAND NAMES - V.V.S.®
PHARMACOLOGIC CATEGORY
Antibiotic, Vaginal
DOSING: ADULTS - Haemophilus vaginalis vaginitis: Intravaginal: Cream: Insert 1 applicatorful in vagina twice daily for 4-6 days. Dosage may then be decreased to 1/2 to 1/4 of an applicatorful twice daily.
DOSING: ELDERLY - Refer to adult dosing.
DOSAGE FORMS - Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, vaginal: Sulfabenzamide 3.7%, sulfacetamide 2.86%, and sulfathiazole 3.42% (78 g with applicator)
DOSAGE FORMS: CONCISE
Cream, vaginal: Sulfabenzamide 3.7%, sulfacetamide 2.86%, and sulfathiazole 3.42% (78 g with applicator)
V.V.S.®: Sulfabenzamide 3.7%, sulfacetamide 2.86%, and sulfathiazole 3.42% (78 g with applicator)
GENERIC EQUIVALENT AVAILABLE - Yes
USE - Treatment of Haemophilus vaginalis vaginitis
ADVERSE REACTIONS SIGNIFICANT - Frequency not defined.
Dermatologic: Pruritus, urticaria, Stevens-Johnson syndrome
Local: Local irritation
Miscellaneous: Allergic reactions
CONTRAINDICATIONS - Hypersensitivity to sulfabenzamide, sulfacetamide, sulfathiazole, or any component of the formulation; renal dysfunction; pregnancy (if near term)
WARNINGS / PRECAUTIONS
Concerns related to adverse effects:
Blood dyscrasias: Severe reactions including agranulocytosis, aplastic anemia and other blood dyscrasias have occurred with sulfonamides (regardless of route).
Dermatologic reactions: Severe reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis have occurred with sulfonamides (regardless of route).
Hepatic necrosis: Fatalities associated with fulminant hepatic necrosis have occurred with sulfonamides (regardless of route).
Hypersensitivity reactions: Rarely, systemic hypersensitivity reactions may occur; use caution if applying to denuded or abraded skin.
Sulfonamide allergy: Chemical similarities are present among sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, thiazides, and loop diuretics (except ethacrynic acid). Use in patients with sulfonamide allergy is specifically contraindicated in product labeling, however, a risk of cross-reaction exists in patients with allergy to any of these compounds; avoid use when previous reaction has been severe.
DRUG INTERACTIONS - No data reported
PREGNANCY RISK FACTOR - C (show table) (avoid if near term)
LACTATION - Excretion in breast milk unknown
INTERNATIONAL BRAND NAMES - Sultrin (AE, BF, BH, BJ, CI, CY, EG, ET, GH, GM, GN, GR, IL, IQ, IR, JO, KE, KW, LB, LR, LY, MA, ML, MR, MU, MW, NE, NG, OM, PH, PT, QA, SA, SC, SD, SL, SN, SY, TN, TZ, UG, YE, ZA, ZM, ZW)
MECHANISM OF ACTION - Interferes with microbial folic acid synthesis and growth via inhibition of para-aminobenzoic acid metabolism
PHARMACODYNAMICS / KINETICS
Absorption: Absorption from vagina is variable and unreliable
Metabolism: Primarily via acetylation
Excretion: Urine
PATIENT INFORMATION - Complete full course of therapy; notify prescriber if burning, irritation, or signs of a systemic allergic reaction occur
 
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Atte,
Usuario
si fuese posible enviar la sintesis del sulfatiazol o la sulfaguanidina te lo agrdeceria muchisimo desde ya muchisima gracias .-